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Sulfasalazine
Sulfasalazine (SalazopyrinŽ) is used dermatologically for the treatment of pyoderma gangrenosum, idiopathic or secondary to ulcerative colitis, Crohn's disease, or collagen vascular disease.
Contraindications:
- Porphyria
- Sensitivity of ASA or sulfa
Precautions:
- Bone marrow suppression can occur. Blood counts before and two weekly early in therapy are indicated.
- Safety in pregnancy has not been established.
- Many drug interactions - consult your compendium.
Adverse effects:
- Nausea, vomiting, GI distress
- Methemoglobinemia
- Bone marrow suppression
- Hypersensitivity reactions, including Stevens-Johnson syndrome.
Dosage:
- Pyoderma gangrenosum may require up to 6 gm daily.
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